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Survival of your autologous RPE-transplanted macaque monkey was observed for only
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, family members and community at huge by means of efforts in cancer prevention and early detection, cancer care access and coordination, insurance coverage coverage and continuity, identification and referral to cancer resources and assistance solutions, and palliative and endof-life care. Patient navigators, specifically these in the exact same neighborhood or with the very same or related cultural background, can minimize fear and anxiousness, make trust, reduce literacy barriers, facilitate patient-provider communication, deliver psychoemotional support and manage logistical obstacles to cancer care.1,15-19 Patient navigators that are not straight involved inside the patient's day-to-day health-related care are specifically vital, as they are able to "be there" for the patient and loved ones in a manner not achievable for members in the patient's quick healthcare group. Sufferers often see the navigator as an insider to the healthcare method, but not a direct part of the technique. The navigator is in a position to recognize the needs on the patient too because the needs on the healthcare system/team and facilitate coordination involving the two whilst keeping the survivor in the forefront and providing both customized emotional support and extensive access to care and resources. Hence, the navigator serves as a bridge betweenSemin Oncol Nurs. Author manuscript; available in PMC 2014 August 26.Krebs et al.Pagethe patient as well as the healthcare technique and may help each to identify tactics that support survival and quality of life. (personal communications NNACC navigators)NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptMultiple authors15-19 have identified the roles and responsibilities of patient navigators when working with cancer individuals, their families/caregivers, and their communities. Irrespective of whether lay patient navigators embedded in their own communities or healthcare providers navigating within and across healthcare systems, the roles and responsibilities from the cancer patient navigator take into account the individuality with the patient, the healthcare atmosphere and the cultural beliefs and mores from the patient, household and neighborhood. Tasks vary by patient, disease elements, cultural beliefs and identity, healthcare systems, plus the qualities with the person navigator. Table two identifies the a variety of roles and responsibilities of cancer patient navigators. Braun and colleagues15 identified the tasks with the cancer patient navigator by way of evaluation of five National Cancer Institute-funded Neighborhood Network Applications that at the moment present cancer patient navigation. These navigation applications incorporated Native American Cancer Research Corporation (NACR), Hands of Hope, PATH for Females, Redes En Acci  National Patient Navigator Intervention Study and Kukui Ahi. The authors utilized two frameworks: the phases from the cancer care continuum plus the "5 A's of excellent care" (to which they added a sixth attribute, understandable) to identify popular tasks of cancer patient navigators. The cancer care continuum involves the six possible phases (education and outreach, screening, diagnosis and staging, treatment, survivorship and finish of life) through which a patient may possibly encounter and knowledge a cancer diagnosis, treatment and follow-up care. These phases aren't exclusive, but rather overlap and may repeat themselves throughout the individual's life. Tasks across the continuum meet the support and resource demands of sufferers during every single precise phase and can vary based
Survival of your autologous RPE-transplanted macaque monkey was observed for only 1 year. Hence, long-term tumorigenicity with the transplanted cells in humans has yet to be ascertained. More than time, the microenvironment for injected cells in situ could lead to late-onset tumorigenic events. There's a affordable possibility that the aforementioned non-integrative, non-retroviral cell reprogramming approach will only postpone the onset of tumorigenesis, as opposed to get rid of the tumorigenic possible on the iPSCs. Granted that the investigation subjects will likely be cautiously monitored for 1 year using a subsequent three-year follow-up, some individuals may possibly realize and accept the dangers of tumorigenicity within the hope that this novel treatment tactic will give them adequate therapeutic rewards. Other sufferers may possibly feel, on the other hand, that these are potentially life-threatening dangers which can be totally avoidable by not participating within the existing research project. In response to the seemingly alarmist description with the tumorigenicity risks of iPSCs presented above, researchers may well explain to individuals that, in worst case scenarios, one particular can constantly get rid of the eye if you'll find any localized adverse events associated with the cell transplant, and that this can be exactly among the reasons why an eye disease was selected for the first-in-human iPSC-based transplant study. Nevertheless, offered the truth that many wet AMD patients continue to preserve peripheral vision of 20/400 and above (as discussed under), some individuals would reasonably choose a 100  possibility of obtaining their minimum vision over a modest opportunity of losing one particular eye, unless they will count on that the transplant will bring them further added benefits. Our subsequent question is no matter whether these risks is often outweighed by possible therapeutic positive aspects.Prospective Added benefits For sufferers, any potential positive aspects of clinical study may be worth pursuing after they can count on that the chance of getting such positive aspects exceeds the benefits from existing remedy or non-treatment solutions, with no struggling with important unwanted side effects. AMD just isn't a fatal illness, however it impacts patient's good quality of life by impacting one's central vision. In line with American Macular Degeneration Foundation, the likely situation for wet AMD sufferers will be a life with visual acuity gradually falling down to somewhere among 20/80 and 20/400, but in some situations it might be worse [33]. Present therapy possibilities for wet AMD include things like (1) month-to-month anti-VEGF (vascular endothelial growth aspect) injections in to the eye to block the development of CNVs and (two) photodynamic therapy or laser surgery to halt the growth of CNVs. Even so, they are not cures, and also the patient's situation could get worse even with therapy. The National Eye Institute's Age-Related Eye Disease Study (AREDS) located that (3) theintake of a particular combination of antioxidants and zinc could decrease the threat of worsening the patients' AMD situation to a specific degree [34]. Regardless of these attempts, it can be correct that more effective therapies that may restore vision are anticipated. In February 2013, FDA approved the Argus II Retinal Prosthesis Program, an implanted retinal prosthesis (artificial retina) connected to a smaller video camera plus a video processing unit [35], but this method requires invasive surgery and unwieldy equipment.
 

รุ่นแก้ไขเมื่อ 15:43, 6 ธันวาคม 2564

, family members and community at huge by means of efforts in cancer prevention and early detection, cancer care access and coordination, insurance coverage coverage and continuity, identification and referral to cancer resources and assistance solutions, and palliative and endof-life care. Patient navigators, specifically these in the exact same neighborhood or with the very same or related cultural background, can minimize fear and anxiousness, make trust, reduce literacy barriers, facilitate patient-provider communication, deliver psychoemotional support and manage logistical obstacles to cancer care.1,15-19 Patient navigators that are not straight involved inside the patient's day-to-day health-related care are specifically vital, as they are able to "be there" for the patient and loved ones in a manner not achievable for members in the patient's quick healthcare group. Sufferers often see the navigator as an insider to the healthcare method, but not a direct part of the technique. The navigator is in a position to recognize the needs on the patient too because the needs on the healthcare system/team and facilitate coordination involving the two whilst keeping the survivor in the forefront and providing both customized emotional support and extensive access to care and resources. Hence, the navigator serves as a bridge betweenSemin Oncol Nurs. Author manuscript; available in PMC 2014 August 26.Krebs et al.Pagethe patient as well as the healthcare technique and may help each to identify tactics that support survival and quality of life. (personal communications NNACC navigators)NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptMultiple authors15-19 have identified the roles and responsibilities of patient navigators when working with cancer individuals, their families/caregivers, and their communities. Irrespective of whether lay patient navigators embedded in their own communities or healthcare providers navigating within and across healthcare systems, the roles and responsibilities from the cancer patient navigator take into account the individuality with the patient, the healthcare atmosphere and the cultural beliefs and mores from the patient, household and neighborhood. Tasks vary by patient, disease elements, cultural beliefs and identity, healthcare systems, plus the qualities with the person navigator. Table two identifies the a variety of roles and responsibilities of cancer patient navigators. Braun and colleagues15 identified the tasks with the cancer patient navigator by way of evaluation of five National Cancer Institute-funded Neighborhood Network Applications that at the moment present cancer patient navigation. These navigation applications incorporated Native American Cancer Research Corporation (NACR), Hands of Hope, PATH for Females, Redes En Acci National Patient Navigator Intervention Study and Kukui Ahi. The authors utilized two frameworks: the phases from the cancer care continuum plus the "5 A's of excellent care" (to which they added a sixth attribute, understandable) to identify popular tasks of cancer patient navigators. The cancer care continuum involves the six possible phases (education and outreach, screening, diagnosis and staging, treatment, survivorship and finish of life) through which a patient may possibly encounter and knowledge a cancer diagnosis, treatment and follow-up care. These phases aren't exclusive, but rather overlap and may repeat themselves throughout the individual's life. Tasks across the continuum meet the support and resource demands of sufferers during every single precise phase and can vary based