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Ocalizations of your ECS elements and also the new techniques proposed to tackle their activity of this receptor open the door to new questions (Table 1). Indeed, the endocannabinoid program has been connected to several physiological and pathologicalTable 1. Open questions inside the cannabinoid receptor-1 (CB1) receptor field. Open questions inside the endocannabinoid field.Distal radial fractures seem to become by far the most common fracture entity presently observed in accident and emergency units, with an annual estimated incidence of 36.six women/10,000 and 8.9 men/10,000 per year [1]. A drastically growing elderly population using a markedly growing life expectancy may perhaps boost the fracture incidence by a further 50 by the year 2030 [2]. Non-operative treatment applying a plaster cast is usually chosen for non-displaced fractures. A steady reduction in displaced fractures might also be treated non-operatively [3]. Unstable and displaced radial fractures are treated operatively. In addition to stability and displacement, intra-articular or extra-articular fracture type may also be significant for the selection. The perfect strategy for surgical management of those fractures has been a controversial topic of discussion, and quite a few procedures are accessible. Percutaneous Kirschner wire fixation, joint-bridging and non-joint-bridging external fixation, or possibly a combination of both can be used effectively [4]. The palmar locking plate has recently turn out to be common [5, 7, 8] for treatment for distal radial fractures, and very good to exceptional clinical final results have already been published [81]. In fact, there are quite a few research demonstrating fantastic results inside the therapy for distal radial fractures with palmar locked angle plates at a big, specialized institution. The limited quantity of specialized institutions coupled together with the rising quantity ofE. Skouras K. Wegmann Klinik und Poliklinik fur Orthopadie und Unfallchirurgie, Universitsklinikum Koln, Kerpener Stra 62, 50937 Cologne, Germany Y. Hosseini V. Berger T. C. Koslowsky ( ) Department of Surgery, St. Elisabeth-Hospital, Werthmannstra 1, 50935 Cologne, Germany e-mail: [email protected] Traum Limb Recon (2013) 8:155distal radial fractures might be leading to a lack of therapy capacity of this injury. The purpose of this potential study was to evaluate the subjective and objective outcome after operative remedy for distal radial fractures utilizing a palmar locked angle miniplate (Koenigsee, two.4 mm T-miniplate) by a smaller, non-specialized institution to evaluate the necessity for referral to high-volume services.Patients and procedures This study was performed at a hospital with a non-specialized trauma service together with the healthcare degree of fundamental trauma and reconstructive surgery. Over a period of three years (2005007), a total of 82 individuals with 84 distal radial fractures (mean age 64 years (184 years); 15 males and 67 females) had been followed prospectively. Preoperative work-up incorporated a clinical examination and regular twoplane X-rays. Right after initial sandwich casting, the operation was performed as an elective procedure using a mean of four days (injury day to day seven) after trauma, except for those sufferers with open fractures (four patients) and/or neurological affection (one patient). In addition to these emergency criteria, indications for surgical intervention had been the following: radial shortening of more than 3 mm; dorsal comminution; dislocation of greater than 20in extra-articular fractures; or an intra-articular step-off of greater than two.