| − | Ssociated using a specimen inside a biobank repository. These included `human topic enrollment', `informed consent process', `document editing' (filling out case report forms), `specimen collection process', `material processing' of your specimen, `storage' of the specimen, and shipping and handling processes. Patient-related termsBrochhausen et al. Journal of Biomedical Semantics (2016) 7:Web page four of(e.g., `smoking behavior') were also integrated. Terms have been re-used from BFO, IAO, OBI, ChEBI, EFO, NCBITaxon, OGMS, PATO, and UBERON. About 50 terms were added to address biobank precise needs (e.g., collection packets for specimens) resulting in 227 classes, 18 men and women, 34 object properties, and 526 logical axioms. From these definitions it really is clear that in the viewpoint of OBIB, a biobank consists of both the specimens plus the data about the specimens plus the specimen collections. OBIB differentiates in between a biobank as well as a biobank organization. The latter is defined as: "An organization bearing legal personality that owns or administrates at least one particular biobank." This differentiation enables concise representation of an organization operating more than a single biobank, as is on a regular basis the case for hospitals, study facilities and other individuals. So, OBIB fills gaps concerning the representation of biobanking which have so far existed in OBO Foundry ontologies and other ontologies.Due to the fact that OBIB is the outcome of merging two independently developed ontologies, coverage is broad. Naturally, it covers info about specimens and processes like specimen collection, specimen handling and storage. Additionally, it represents donors and patients and healthcare record information pertaining to these. Also, it provides representation for clinical studies and specimens and information accrued in the course of these. In the existing release, the OBIB-generated terms are associated for the containment in the specimen (e.g., OBIB_0000028: collection packet), additives (e.g. OBIB_0000022: blood additive function), and storage mechanisms (e.g., OBIB_0000030: blood spot card). OBIB precise terms were also generated for patient types (e.g., OBIB_0000017: data confirm questionnaire) and related health-related concerns (e.g., OBIB_0000053: duration time of smoking). Most terms needed by OBIB usually are not specific to biobanks and out there from other OBO ontologies and imported. Figure 2 shows a collection of probably the most relevant classes of OBIB and their superclasses. The figure shows that lots of classes in OBIB are re-used from other generally utilized ontologies in the biomedical domain, like OBI, IAO, and other individuals, or subclasses of those classes. Notably, a number of these are central classes including "specimen" and "specimen collection", both re-usedFig. two Choice of central classes of OBIB and their superclasses. The leftmost four BFO classes are subclasses of additional BFO classes that are not shown here for readabilityBrochhausen et al. Journal of Biomedical Semantics (2016) 7:Page 6 offrom OBI. Other OBI classes, which include "organization" and "material maintenance" are superclasses for classes extremely relevant for the biobanking domain, such as "biobank organization" and "specimen freezing". This not just highlights the relevance of OBI for the representations that happen to be component of OBIB, but also provides a crucial opportunity concerning the use of semantic internet technologies in translational analysis. Terms like "specimen" are made use of by several ontologies. The National Center for Biomedical Ontologi.
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