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Essing Protein catabolism Cytoskeleton Response to anxiety Cell cycle Cell adhesion Immune response Protein transport Apoptosis Ion transport Protein translation Protein processing Miscellaneous UnknownBiological function Transcription Signalling Metabolism RNA processing Protein catabolism Cytoskeleton Response to stress Cell cycle Cell Adhesion Immune response Apoptosis Ion transport Protein transport Miscellaneous UnknownThe relative number of genes differentially expressed in SALS compared with PLS fibroblasts is also supplied. Response to pressure and RNA processing will be the categories that are altered most in SALS, compared with the PLS fibroblasts.Table 2. Top 20 gene ontology biological processes altered in SALS fibroblasts as determined by the functional annotation chart applying the DAVID analysis computer software No. of genes 84 96 73 69 34 15 9 7 7 30 19 23 24 17 17 30 four 24 15 16 differentially expressed genes 22.05 25.20 19.16 18.11 8.92 three.94 two.36 1.84 1.84 7.87 four.99 6.04 six.30 4.46 4.46 7.87 1.05 six.30 three.94 4.Gene ontology biological approach GO:0006350transcription GO:0045449regulation of transcription GO:0051252regulation of RNA metabolic process GO:0006355regulation of transcription, DNAdependent GO:0006357regulation of transcription from RNA polymerase II promoter GO:0010608posttranscriptional regulation of gene expression GO:0040029regulation of gene expression, epigenetic GO:0042593glucose homeostasis GO:0033500carbohydrate homeostasis GO:0010605negative regulation of macromolecule metabolic approach GO:0016071mRNA metabolic process GO:0010629negative regulation of gene expression GO:0010558negative regulation of macromolecule biosynthetic method GO:0043009chordate embryonic improvement GO:0009792embryonic development ending in birth or egg Brequinar Purity & Documentation hatching GO:0042127regulation of cell proliferation GO:0032350regulation of hormone metabolic approach GO:0009890negative regulation of biosynthetic method GO:0008380RNA splicing GO:0006397mRNA processingPvalue 7.13E10 1.65E09 1.21E08 1.39E07 1.45E05 1.15E04 1.73E04 four.66E04 four.66E04 5.21E04 six.26E04 7.01E04 eight.74E04 0.0013 0.0014 0.0015 0.0016 0.0016 0.0022 0.For each course of action, the number and percentage of differentially expressed genes as well as the statistical significance has been shown.2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley Sons Ltd on behalf of British Neuropathological SocietyNAN 2015; 41: 201ALS PLS fibroblasts as cell models for sporadic diseaseTable three. Major 20 gene ontology biological processes altered in PLS fibroblasts as determined by the functional annotation chart applying the DAVID analysis computer software No. of genes 9 16 four 14 6 20 10 six six 36 7 35 3 19 46 9 6 5 7 four differentially expressed genes four.64 eight.25 two.06 7.22 three.09 10.31 five.15 three.09 3.09 18.56 three.61 18.04 1.55 9.79 23.71 four.64 three.09 two.58 three.61 two.Gene ontology biological process GO:0043627response to estrogen stimulus GO:0009719response to endogenous stimulus GO:0010559regulation of glycoprotein biosynthetic approach GO:0009725response to hormone stimulus GO:0032355response to estradiol stimulus GO:0010033response to organic substance GO:0042493response to drug GO:0030217T cell differentiation GO:0033273response to vitamin GO:0051252regulation of RNA metabolic procedure GO:0030098lymphocyte differentiation GO:0006355regulation of transcription, DNAdependent GO:0010560positive regulation of glycoprotein biosynthetic process GO:0006357regulation of transcription from RNA polymerase II promoter GO:0045449regulation of.