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Ript NIH-PA Author Manuscript NIH-PA Author ManuscriptAnnu Rev Biochem. Author manuscript Ript NIH-PA Author Manuscript NIH-PA Author ManuscriptAnnu Rev Biochem. Author manuscript; available in PMC 2013 February 06.Carman and HanPageThe phosphorylation of Opi1p at Ser10, Ser31, and Ser251 stimulates its repressor function (172), whereas phosphorylation at Ser26 attenuates its repressor function (171). The regulation of Opi1p function via phosphorylation by protein kinases A and C occurs in cells grown in the absence and presence of inositol (171, 172), whereas the regulation via phosphorylation by casein kinase II occurs only when cells are grown in the absence of inositol (173). Opi1p possesses binding domains for PA, Scs2p, Ino2p, and Sin3p (Figure 4) (110, 112, 174, 175), whic.