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D in the lungs, bacterial numbers do not appreciably increase, and D in the lungs, bacterial numbers do not appreciably increase, and the infection does not progress to a debilitating and deadly pneumonia. While Pla is necessary for the progression of both bubonic and pneumonic plague, it seems to have opposing contributions to virulence depending on the route of infection. During bubonic plague, Pla is necessary for bacterial dissemination and inhibition of immune cell recruitment, yet does not affect bacterial growth at the local site of infection. In contrast, following intranasal infection, Pla is necessary for outgrowth of the bacteria in the lungs by aiding either growth or Darapladib In stock survival in this environment, yet is dispensable for dissemination. It remains.