หน้าหลัก

R Aqp4 counterparts, cause astrocyte cell death, and trigger CNS inflammation. R Aqp4 counterparts, cause astrocyte cell death, and trigger CNS inflammation. Finally, we described induction of CNS inflammation in mice upon active immunization with AqpZ protein or homologous AqpZ and Aqp4 peptides, which was associated with T cell cross-reactivity between them. Based on these Title Loaded From File results, we concluded that bacterial AqpZ and human Aqp4 proteins share significant structural homology and cross-react in immune-based assays and experimental systems. Thus, our study provides direct evidence that infection-induced cross-reactivity may be involved in the induction of the autoimmune response against Aqp4 in NMO. The findings of our study are novel and provide a new perspective on t.