หน้าหลัก

The E. coli system, to provide a foundation for future structure-based The E. coli system, to provide a foundation for future structure-based design of inhibitors that disrupt the M. tuberculosis thioredoxin system, either as chemical probes of function, or as potential anti-mycobacterial agents. Analysis of structures and models for various steps in the M. tuberculosis thioredoxin catalytic cycle, as opposed to individual static snapshots of single proteins (ex. TrxR), may suggest novel strategies for inhibition. The thioredoxin system in M. tuberculosis is comprised of three thioredoxins (TrxA, TrxB, and TrxC) and one thioredoxin reductase (TrxR).3, 24, 25 It has been shown that M. tuberculosis TrxB and TrxC behave as general disulfide reductases with near e.